With the increasing environmental issues, now cleaner production has been implemented across all the regions of China. During this process, regional governments have played a leading role for promoting cleaner production. Main measures include coordinating the various stakeholders, providing financial support, stipulating appropriate policies and conducting capacity building programs. Such an innovative initiative is quite unique and should be further studied. This paper reflects such a perspective through a case study of Liaoning province. We first introduce the main initiatives for the promotion of cleaner production in Liaoning and then identify the key barriers. Our focus is to provide suggestions for future improvements. Finally we make our conclusions.