人才队伍
  • 徐慧研究员

    学历:博士

    学科:环境微生物学;微生物生态学

    电话:024-83970369

    邮箱:xuhui@iae.ac.cn

    地址:沈阳市沈河区文化路72号

    邮编:110016

简历介绍

   2015.6-至今,永利娱高ylg060net工作,研究员

   2013.6-2015. 6,永利娱高ylg060net工作,生物资源与生物技术中心副主任、研究员

   2008.6-2013. 6,永利娱高ylg060net工作,研究员

   2005.9-2008. 6,永利娱高ylg060net工作,开放重点实验室副主任、研究员

   2002.5-2005. 9,永利娱高ylg060net工作,开放重点实验室副主任、副研究员(期间:2002. 4 - 2002.12,比利时根特大学微生物生态与技术实验室合作研究)

   1999.9-2002. 5,永利娱高ylg060net工作,开放重点实验室主任助理、副研究员

   1996.3-1999. 9,永利娱高ylg060net工作,助理研究员

  (期间:1996.3 - 1997.2,丹麦哥本哈根大学理学院,微生物学系合作研究)

   1993.9-1996.2,永利娱高ylg060net学习,获得微生物学博士学位

   1990.9-1993.7,永利娱高ylg060net学习,获得微生物学硕士学位

   1986.9-1990.7,辽宁大学生物系微生物学习,获得微生物学学士学位


研究领域

    环境微生物学

微生物生态学和工业发酵新技术等研究

社会任职

获奖及荣誉

2022年,获“侨界贡献奖”二等奖;

2022年,获“辽宁省先进工作者”称号;

2019,获农业农村部神农中华农业科技二等奖(农田温室气体监测体系创建与稳产减排技术应用),第二完成人;

2018年,获第八届沈阳市十大科技英才提名奖;

2018年,入选沈阳市第一批领军人才;

2017年,获辽宁省科技进步一等奖(Vc发酵伴生依赖性解除及环境友好生产新技术),第一完成人;

2013年,获辽宁省科技进步二等奖(Vc一步高浓度连续发酵新工艺),第一完成人;

2012年,获沈阳市科技进步一等奖(Vc一步高浓度连续发酵新工艺),第一完成人;

2010年,获鞍山市科技进步二等奖(应用Vc发酵废弃物生产多肽复合肥),第二完成人;

2006年,辽宁省科技进步三等奖Vc二步发酵卫星搭载菌及其适宜工艺),第四完成人;


承担科研项目情况

1. 宁波科技援疆项目,库车市农业微生态技术实验室运营项目,2021-20251200万元,主持。

2. 国家重点研发子课题,维C发酵伴生依赖性解除技术及废渣液资源化利用,2021-2025,112万元,子课题负责人。

3. 沈阳市重大科技成果转化项目,Vc 废母液合成 Vc-Na 并生产生物有机肥新技术转化,2020-2022,100万元,主持。

4. 院企合作课题,Vc废母液提取古龙酸并制备Vc-Na新技术,2019-2023,150万元,主持。

5. 院企合作课题,Vc废母液制备(生物)有机肥新技术,2019-2023,150万元,主持。

6. 院企合作课题,用于食品、保健食品的微生物菌剂及系列产品开发, 2018-2021,100万元,主持。

7. 沈阳市科技创新“双百”工程项目,VC发酵伴生依赖性解除及母液再提取技术转化,2017-2018,100万元,主持。

8. 院企合作课题,Vc废母液的资源化利用新技术及产业化,2017-2019,50万元,主持。

9. 院企合作课题,Vc废菌渣再利用新技术及其应用,2017-2019,45万元,主持。

10. 院企合作课题,环保菌剂研发与应用,2016-2020,125万元,主持。

11. 国家公益性行业科研专项课题,东北旱地农田温室气体监测与控制技术研究,2011-2015,267万元,主持。

12. 沈阳市科技攻关项目,剩余活性污泥高效深度脱水技术开发,2011-2013,70万元,主持。

13. 国家支撑计划课题,旱地固碳增汇及氧化亚氮减排技术研究与示范2009-2011,208万元,主持。

14. 国家新药创制科技重大专项,磷霉素及其系列产品技术升级研究,2008-2010,45万元,子课题负责人。

15. 国家自然科学基金,土壤N2O和CH4排放/吸收微生物过程的双向性耦合关系2007-2009,28万元,主持。

16. 院企合作课题,Vc发酵高效菌系构建2007-2010,58万元,主持。


发表论文情况

1. Dan Dong, Weichao Yang*, Hao Sun, Mingfu Gao, Shuang Kong, Hui Xu*. Fertilization regimes impacts CO2 emission of rainfed maize field in an acidic luvisol. Plant and Soil, 2024. https://doi.org/ 10.1007/s11104-024-06572-3

2. Meijun Shi, Mingfu Gao, Hao Sun, Weichao Yang, Hongxia Zhao, Lixin Zhang, Hui Xu*,Exogenous 2-keto-L-gulonic acidsupplementation as a novelapproach to enhancing L-ascorbicacid biosynthesis in Zebrafish (Daniorerio). Animals, 2023, 13, 2502.

3. Dan Dong#, Weichao Yang#, Hao Sun, Shuang Kong, Hui Xu*. Effects of animal manure and nitrification inhibitor on N2O emissions and soil carbon stocks of a maize cropping system in Northeast China. Scientific Reports, 2022, 12, 15202.

4. Dongxu Ji, Hao Sun*, Weichao Yang, Mingfu Gao, and Hui Xu*. Transfer of Human Microbiome to Drosophila Gut Model. Microorganisms, 2022, 10, 553. https://doi.org/10.3390/ microorganisms10030553.

5. Dan Dong, Weichao Yang*, Hao Sun, Shuang Kong, Hui Xu*. Effects of split application of urea on greenhouse gas and ammonia emissions from a rainfed maize field in northeast China. Frontiers in Environmental Science, 2022, 743.

6. Mingfu Gao, Hao Sun, Meijun Shi, Qiqi Wu, Dongxu Ji, Bing Wang, Lixing Zhang, Yang Liu, Litao Han, Xicheng Ruan, Hui Xu*, Weichao Yang*. 2-keto-L-gulonic acid improved the salt stress resistance of non-heading Chinese cabbage by increasing L-ascorbic acid accumulation. Frontiers in Plant Science, 2021, 12, 697184.

7. Dan Dong, Weichao Yang*, Hao Sun, Shuang Kong, Hui Xu*. Nitrous oxide emissions in response to long-term application of the nitrification inhibitor DMPP in an acidic luvisol. Applied Soil Ecology, 2021, 159, 103861.

8. Weichao Yang, Hao Sun, Dan Dong, Shuang Ma, Manddla*, Zhenxing Wang, Hui Xu*. Enhanced 2-keto-L-gulonic acid production by a mixed culture of Ketogulonicigenium vulgare and Bacillus megaterium using three-stage temperature control strategy. Brazilian Journal of Microbiology,2020,52, 257-265.

9. Shuang Ma, Hao Sun, Weichao Yang, Mingfu Gao, Hui Xu*. Impact of Probiotic Combination in InR[E19]/TM2 Drosophila melanogaster on Longevity, Related Gene Expression, and Intestinal Microbiota: A Preliminary Study. Microorganisms,2020,8, 1027.

10. Yuting Li, Hao Sun, Weichao Yang, Guanxiong Chen, Hui Xu*. Dynamics of Bacterial and Viral Communities in Paddy Soil with Irrigation and Urea Application. Viruses, 2019, 11(4), 347.

11. Yuting Li, Hao Sun, Beibei Du, Hui Xu*. Gut Microbiota Shifts in Pup Athymic BALB/c Mice. An Updated Identification in Nude Mice, Animals, 2019, 9(4), 151.

12. Dan Dong, Yongping Kou, Weichao Yang, Guanxiong Chen, Hui Xu*. Effects of urease and nitrification inhibitors on nitrous oxide emissions and nitrifying/denitrifying microbial communities in a rainfed maize soil: A 6-year field observation. Soil and Tillage Research, 2018, 180, 82-90.

13. Hao Sun,Yuting Li, and Hui Xu*, Is Endophyte-Plant Co-Denitrification a Source of Nitrous Oxides Emission?-An Experimental Investigation with Soybean. Agronomy, 2018, 8, 108.

14. Weichao Yang, Litao Han, Mandlaa Mandlaa, Haihong Zhang, Zhongze Zhang, Hui Xu*, A plate method for rapid screening of Ketogulonicigenium vulgare mutants for enhanced 2-keto-L-gulonic acid production, Brazilian Journal of Microbiology, 2017, 48, 397-402.

15. Weichao Yang, Litao Han, Mandlaa Mandlaa, Hongquan Chen, Mingyan Jiang, Zhongze Zhang, Hui Xu*, Spaceflight-induced enhancement of 2-keto-L-gulonic acid production by a mixed culture of Ketogulonigenium vulgare and Bacillus thuringiensis, Letters in Applied Microbiology, 2013, 57, 54-62.

16. Mandlaa#,Weichao Yang#, Litao Han, Zhenyu Wang, Hui Xu*, Two-helper-strain co-culture system: a novel method for enhancement of 2-keto-L-gulonic acid production, Biotechnology Letters, 2013, 35, 1853-1857.

17. Weichao Yang, Hui Xu*. Industrial fermentation of vitamin C, in Industrial Biotechnology of Vitamins, Biopigments, and Antioxidants,1st edn (eds E.J. Vandamme and J.L. Revuelta), Wiley-VCH Verlag GmbH & Co. KgaA, 15400, 2016.

18. Mandlaa, Weichao Yang*, Chengbin Liu, Hui Xu*. L-sorbose is not only a substrate for 2-keto-l-gulonic acid production in the artificial microbial ecosystem of two strains mixed fermentation. Journal of Industrial Microbiology & Biotechnology, 2015, 42, 897-904.

19. Yuling Dong, Hao Sun, Weichao Yang, Shuang Ma, Beibei Du, Hui Xu*. The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study. Nutrients, 2019, 11(3), 636.

20. Yuling Dong, Zhenyu Wang, Hao Sun, Weichao Yang, Hui Xu*. The response patterns of arbuscular mycorrhizal and ectomycorrhizal symbionts under elevated CO2: a meta-analysis. Frontiers in Microbiology, 2018, 9, 01248.

21. Zhenyu Wang, Tao Kong, Song Hu, Hao Sun, Weichao Yang, Yongping Kou, Mandlaa Mandlaa, Hui Xu*. Nitrification inhibitors mitigate earthworm-induced N2O emission- a mesocosm study. Biology and Fertility of Soils, 2015, 1005-1011.

22. Y.P. Kou, K. Wei, G.X. Chen, Z.Y. Wang, Hui Xu*, Effects of 3,4-dimethylpyrazole phosphate and dicyandiamide on nitrous oxide emission in a greenhouse vegetable soil. Plant Soil and Environment, 2015, 61(1): 29–35.

23. Tao Kong, Hui Xu*, Zhenyu Wang, Hao Sun, Lihua Wang. Effect of a residue after evaporation from industrial vitamin C fermentation on chemical and microbial properties of alkali-saline soil.Pakistan Journal of Pharmaceutical Sciences, 2019, 1069-1074.

24. Zongwei Xia, Hui Xu*, Guanxiong Chen, Dan Dong, E. Bai, Liangguo Luo. Soil N2O production and the δ15N-N2O value: Their relationship withnitrifying/denitrifying bacteria and archaea during a growing season of soybean in northeast China. European Journal of Soil Biology, 2013(58): 73-80.

25. Yanling Guo, Liangguo Luo, Guanxiong Chen, Yongping Kou, Hui Xu*. Mitigating nitrous oxide emissions from a maize-cropping black soilin northeast China by a combination of reducing chemical Nfertilizer application and applying manure in autumn. Soil Science and Plant Nutrition ,2013, doi.org/10.1080/00380768.2013.775006.

26. Rongjiu Shi*, Ying Zhang, Weichao Yang, Hui Xu*. Microbial community characterization of an UASB treating increased organic loading rates of vitamin C biosynthesis wastewater. Water Science and Technology, 2012, 65, 254-261.

27. R.Shi, H.Xu, Y.Zhang, Enhanced treatment of wastewater from the vitamin C biosynthesis industry using a UASB reactor supplemented with zero-valent iron. Environmental Technology 2011,32, 1859-1865.

28. Hui Li, Ying Zhang, Dong-sheng Li, Hui Xu, Guan-xiong Chen, Cheng-gang Zhang. Comparisons of different hypervariable regions of rrs genes for fingerprinting of microbial communities in paddy soils. Soil Biology & Biochemistry 2009, 41: 954~968.

29. Jun-jie Lin, Xiao-song Zhao, Dan Liu, Zhi-guo Yu, Ying Zhang, Hui Xu*. 2008. The decoloration and mineralization of azo dye C.I. Acid Red 14 by sonochemical process: Rate improvement via Fenton’s reactions. Journal of Hazardous Materials 157: 541–546.

30. Xunhua Zheng, Baoling Mei, Yinghong Wang, Baohua Xie, Yuesi Wang, Haibo Dong, Hui Xu, Guanxiong Chen, Zucong Cai, Jin Yue, Jiangxin Gu, Fang Su, Jianwen Zou, Jianguo Zhu. Quantification of N2O fluxes from soil-plant systems may be biased by the applied gas chromatograph methodology. Plant and Soil. 2008, 311(1-2): 211-234.

31. Li Nan, Weichao Yang, Yongqian Liu, Hui Xu, Ying Li, Manqi Lu, Ke Yang*. 2008. Antibacterial mechanism of copper-bearing antibacterial stainless steel against E.coli. Journal of Materials Science and Technology. 24(2): 197-201.

32. Rongjiu Shi, Ying Zhang, Hui Xu*, Zhe Zhang, and Chenggang Zhang.Pretreatment of Distillery Wastewater from Vitamin C Synthesis Industry by Upflow Anaerobic Sludge Blanket (UASB) Reactor. Environmental Engineering Science. 2007, 24(9): 1333-1337.

33. Hui Li, YingZhang, Irina Kravchenko, Hui Xu, Cheng-Gang Zhang. Dynamic Changes in Microbial Activity and Community Structure during Biodegradation of Petroleum Compounds: A Laboratory Experiment. Journal of Environmental Sciences, 2007, 19(8)1003-1013.

34. Hui Xu, Sunny Aiyuk, Ying Zhang, Guanxiong Chen, Willy Verstraete. Stimulation of methanogenesis in a laboratory scale UASB reactor treating domestic sewage by Fe(0) application. Environmental Technology. 2004, Vol 25: 613-619.

35. Y. Zhang, S. Aiyuk, H. Xu, G.X. Chen, W. Verstraete. 2004, Study of microbial communities in UASB reactor treating municipal wastewater by denaturing gradient gel electrophoresis of 16S rDNA. Science in China. Ser. C Life Sciences, 47 Supp. 1-8

36. Accoe Frederik, Boeckx Pascal, Van Cleemput Oswald, Hofman Georges, Hui Xu, Bin Huang and Guanxiong Chen. Characterization of soil organic matter fractions from grassland and cultivated soils via C content and 13C signature. Rapid Communications in Mass Spectrometry. 2002, 16:1-8.

37. Hui Xu, Bin Huang, Xiujun Zhang, Shijie Han, Guohong Huang. Aboveground vertical concentration profiles of nitrous oxide within coniferous-deciduous mixed forests. Chemosphere: Global Change Science. 2001, 3(2): 145-146.

38. 王立刚,邱建军,徐慧等,农业源温室气体监测技术规范与控制技术研究,科学出版社,2016.

授权发明专利

1. 专利名称:Regulating solution, fertilizer and soil conditioner for increasing vitamin C content of plants as well as preparation and application thereof, 发明人:Xu Hui, Yang Weichao, Sun Hao, Gao  Mingfu,Kong Shuang, Ruan Xicheng, Xu haozhe, LiuYang, 2020-5-25, WIPO, AU2021104231, 授权公告日:2021825

2. 专利名称:一种虫草素转化为3-脱氧肌苷的生物转化方法;发明人:徐慧,肖璇,杨伟超;专利号:ZL201810022149.8;授权公告日:20201229

3. 专利名称:一种以北虫草废弃培养基和维生素C发酵废弃物古龙酸母液生产有机肥及其制备方法;发明人:杨伟超,徐慧,张忠泽,孔涛,张愿伟;专利号:ZL201310694730.1;授权公告日:201868

4. 专利名称:一种适于盐碱地的玉米种子包衣剂及其制备方法;发明人:徐慧,寇涌苹,王力华,于景华;专利号:ZL201410714235.7;授权公告日:2017111

5. 专利名称:一种具有壮根、壮苗和保水功能的玉米种子包衣剂及其制备方法;发明人:徐慧,蔻涌苹,王力华,于景华;专利号:ZL201410708646.5;授权公告日:2016713

6. 专利名称: 一种利用三种菌混合发酵转化山梨糖2-酮基-L-古龙酸的方法;发明人:杨伟超,徐慧,满都拉,张忠泽,安海英,胡昊,李英杰,韩利涛,姜铭妍,谌明,徐静,曹桂环;专利号:ZL201210453539.3;授权公告日:201418

7. 专利名称:一种北方旱地农田土壤的N2O减排方法;发明人:郭彦玲,徐慧,夏宗伟,董丹,孔双,韩斯琴;专利号:ZL201210239406.6;授权公告日:201418

8. 专利名称:一种区分土壤N2O微生物排放源的方法;发明人:夏宗伟,徐慧,陈冠雄,董丹,孔双,韩斯琴;专利号:ZL201210239481.2;授权公告日:2014924

9. 专利名称:一种古龙酸的高温发酵的方法;发明人:陈宏权,徐慧,吕淑霞,安海英,杨伟超,邵立东,姜铭妍,宫英姿,姚岚,荆士华,韩利涛,朱葛,张忠泽;专利号:ZL201110329992.9;授权公告日:2014723

10. 专利名称:一种侧耳素发酵液生产植物营养剂及其方法;发明人:徐慧,韩斯琴,马学军,孔涛,满都拉,王力华;专利号:ZL201110395085.4;授权公告日:2013109

11. 专利名称:生物催化菌株在把右旋磷霉素转变为左旋磷霉素中的应用;发明人:徐慧,王若超,杨伟超,周丽沙,韩斯琴,孔双,纪悦,周凯,赵华,季光辉,金玉坤;专利号:ZL201010616042.X;授权公告日:2013320

12. 专利名称:以维生素C发酵废弃物生产菌体蛋白和多肽有机肥的方法;发明人:徐慧,杨伟超,张颖,李慧,史荣久,韩斯琴,季光辉,宋红军,张忠泽;专利号:ZL200910248459.2;授权公告日:20120704

13. 专利名称:以右旋磷霉素为底物的左旋磷霉素生物转化菌株筛选检定方法;发明人:张雪姝,徐慧,张颖,陈冠雄,陈玉,张海燕;专利号:ZL200610046425.1;授权公告日:20121114

14. 专利名称:一种剩余活性污泥的深度脱水方法;发明人:徐慧,李娜娜,吕淑霞,杨伟超,张忠泽;专利号:ZL201010101618.9;授权公告日:2011518

15. 专利名称:一种染料废水的处理材料及处理方法;发明人:徐慧,林俊杰,吕曼祺,张颖,李慧,史荣久,韩斯琴,杨伟超;专利号:ZL200710159115.5;授权公告日:201062

16. 专利名称:一种阿特拉津除草剂降解菌的菌剂制备方法;发明人:李慧,徐慧,张颖,韩斯琴,史荣久,倪志龙,杨伟超,张忠泽,陈冠雄;发明专利号:ZL200710012981.1;授权公告日:2010331

17. 专利名称:一种磷霉素产生菌株的筛选方法;发明人:周丽沙,徐慧,李佰广,张颖,李慧,任瑞霞,张忠泽;专利号:ZL200610134746.7;授权公告日:2010616

18. 专利名称:一种把右旋磷霉素转变为左旋磷霉素的方法;发明人:徐慧,周丽沙,张颖,李慧,李启平,季光辉,杨伟超,史荣久,韩斯琴,倪志龙;专利号:ZL200710012579.3;授权公告日:2010728

19. 专利名称:测定气体样品N2O浓度中双进样口进样实现反吹的方法;发明人:徐慧,陈冠雄,于克伟,张颖,荆瑞勇,倪志龙,郑循华;专利号:ZL200410050256.X;授权公告日:2009415

20. 专利名称:一种利用硫代巴比妥酸法测定抗菌不锈钢抗菌性能的方法;发明人:杨伟超,徐慧,张颖,李慧,任瑞霞,韩斯琴,陈冠雄,吕曼祺,南黎,杨柯;专利号:ZL 2007 1 0010621.8;授权公告日:200963

21. 专利名称:利用古龙酸母液生产的抗生土壤改良剂及其制备方法;发明人:徐慧,张颖,李慧,任瑞霞,赵军,刘海涛,张海宏,张忠泽;专利号:ZL200610134528.3;授权公告日:20081210

22. 专利名称:一种磷霉素生物转化菌株的筛选方法;发明人:李智峰,徐慧,张雪姝,张颖,陈冠雄,张忠泽,王兰君,陈玉;专利号:ZL200510045858.0;授权公告日:2007117

23. 专利名称:一种提高上流式厌氧污泥床处理效率的方法及其装置;发明人:徐慧,陈冠雄,张颖,史荣久,李欣;专利号:ZL03134017.2;授权公告日:200614

24. 专利名称:一种磺胺嘧啶废水好氧生物处理菌株的简易筛选方法;发明人:徐慧,史荣久,张颖,朗咸明,王卓,陈冠雄;专利号:ZL200510045857.6;授权公告日:20061220

25. 专利名称:一种复合型生物添加剂及其制备方法和应用;发明人:张颖,徐慧,史荣久,陈冠雄;专利号ZL200310105272.X;授权公告日: 2006510

26. 专利名称:以顺丙烯磷酸为底物的左旋磷霉素生物转化菌株筛选方法;发明人:徐慧,李智峰,张雪姝,张颖,陈冠雄,张忠泽,王兰君,陈玉;专利号:ZL200510045889.6;授权公告日:2006118

27. 专利名称:利用阴极氢提高上流式厌氧污泥床处理效率的装置及应用;发明人:徐慧,史荣久,陈玉,郎咸明,陈冠雄,张颖,于克伟;专利号:ZL200410021587.0;授权公告日:20061011


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