女，生于1988年1月，吉林通化人，博士，助理研究员。

联系方式

Email: baiy@iae.ac.cn

研究方向

特境微生物次级代谢产物及其活性研究。

教育及工作经历

2007年9月-2011年7月  河北医科大学        药学        本科

2011年9月-2014年7月  沈阳药科大学        天然药物化学  硕士

2014年9月-2017年7月  沈阳药科大学        药物分析学    博士

2017年7月-2017年12月  四川科伦药物研究院              分析研究员

2018年4月-至今      中科院沈阳应用生态研究所          助理研究员

发表论文

1. Yan Bai, Xiaodong Ma, Duo Ren, Guoqing Yu, Jiangchun Hu, Huiming Hua, Huaqi Pan*. Peniapyrones A-I,Cytotoxic Tricyclic-Fused α-Pyrone Derivatives from an Endophytic Penicillium brefeldianum F4a. J Nat Prod. 2024, 87(6):1643-1651.
2. Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Jiangchun Hu, and Huaqi Pan*. Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Arabian Journal of Chemistry, 2024, 17, 105388. 

3. Yan Bai, Duo Ren, Fenglin Li, Jiangchun Hu, Huaqi Pan*. Genome mining and molecular networking guided isolation of antimycin analogues with antifeedant activities from the deep-sea-derived Streptomyces sp. NA13. Chemistry & Biodiversity, 2023, 20, e202300715. 
4. Yan Bai, Ping Yi, Fenglin Li, Jiangchun Hu, Huaqi Pan*. Penipentenone A and brefeldin A derivatives potently inhibit KRAS mutant cancer cells from an endophytic fungus Penicillium brefeldianum F4a. Phytochemistry, 2022, 200: 113243. 

5. Xueying Xie, Zexi Zhao, Hetong Yang, Huaqi Pan, Changxiang Zhu, Jiangchun Hu, Yan Bai*. Nigirpexin E, a new azaphilone derivative with anti-tobacco mosaic virus activity from soil-derived fungus Trichoderma afroharzianum LTR-2. The Journal of Antibiotics, 2022, 75 (2), 117-121. 
6. Yan Bai, Ping Yi, Songya Zhang, Jiangchun Hu, Huaqi Pan*. Novel antioxidants and -glycosidase and protein tyrosine phosphatase 1B inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Journal of Fungi, 2021, 7, 913.

7. Yan Bai, Ping Yi, Yun Zhang, Jiangchun Hu, Ying Wang, Jianhua Ju, Huaqi Pan*. Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01. The Journal of Antibiotics, 2021, 74 (11), 799-806. (Highlighted article)
8. Yan Bai, Qili Zhang, Baoyu Wang, Meiyan Zhang, Yan Xu, Shasha Li, Yunli Zhao*, Zhiguo Yu*. Plasma pharmacokinetics, bioavailability, and tissue distribution of four C-glycosyl flavones from mung bean (Vigna radiata L.) seed extracts in rat by ultrahigh-performance liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 2017, 65 (27): 5570-5580.

9. Yan Bai, Yan Xu, Baoyu Wang, Shasha Li, Feng Guo, Huiming Hua, Yunli Zhao*, Zhiguo Yu*. Comparison of phenolic compounds, antioxidant and antidiabetic activities between selected edible beans and their different growth periods leaves. Journal of Functional Foods, 2017, 35: 694-702. 
10. Yan Bai, Jiawei Chang, Yan Xu, Dan Cheng, Hongxin Liu, Yunli Zhao, Zhiguo Yu*. Antioxidant and myocardial preservation activities of natural phytochemicals from mung bean (Vigna radiata L.) seeds. Journal of Agricultural and Food Chemistry, 2016, 64 (22): 4648-4655. 
11. Yan Bai, Yan Xu, Jiawei Chang, Xiaoxue Wang, Yunli Zhao, Zhiguo Yu*. Bioactives from stems and leaves of mung beans (Vigna radiata L.). Journal of Functional Foods, 2016, 25: 314-322. 

12. Yan Bai, Dahong Li, Tingting Zhou, Ningbo Qin, Zhanlin Li, Zhiguo Yu*, Huiming Hua*. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. Journal of Functional Foods, 2016, 20: 453-462.
13. Xiaoying Zhang, Chunfeng Song, Yan Bai, Jiangchun Hu, Huaqi Pan*. Cytotoxic and antimicrobial activities of secondary metabolites isolated from the deep？sea？derived Actinoalloteichus cyanogriseus 12A22. 3 Biotech, 2021, 11: 283.
14. 刘晶莹, 白岩, 潘华奇, 胡江春. 卡伍尔氏链霉菌NA4的 型聚酮基因簇的靶向激活及其产物鉴定. 微生物学报, 2023, 63 (10): 3891-3904.

15. 石逸冰, 白岩, 潘华奇, 胡江春. 植物内生真菌F4a次级代谢产物的分离鉴定以及降血糖、抗氧化活性的研究. 微生物学杂志, 2022, 42 (2): 26-31.