个人基本情况:
姓名:王雨曦
性别:女
联系方式:wangyuxi@iae.ac.cn;024-83970348
通讯地址:辽宁省沈阳市沈河区文化路72号
研究方向:食药用真菌的资源挖掘与利用,包括天然活性先导化合物的发现、鉴定、合成及药效作用机制。
学习和工作经历
2023.06至今,永利娱高ylg060net,生物多样性组(菌物),副研究员
2020.09-2023.05,永利娱高ylg060net,生物多样性组(菌物),特别研究助理/博士后
2015.09-2020.06,沈阳药科大学,天然药物化学,博士
2011.09-2015.06,沈阳药科大学,中药学,学士
承担项目情况
1、国家自然科学基金青年项目:基于分子网络的中国灵芝属次代产物挖掘及其与物种对应关系的构建,30万元,2022-2024,主持
2、中国博士后科学基金面上项目:宽孢灵芝中联苯醚类抗耐药菌活性先导化合物的定向挖掘及生物合成,8万元,2022-2023,主持
3、永利娱高ylg060net“绿埜优秀青年科学家计划”人才项目:100万元,2023-2026,主持
4、国家自然科学基金联合基金项目:云南重要革菌资源多样性的挖掘和保护,231万元,2022-2025,参与
5、国家自然科学基金面上项目:苦木和臭椿中靶向Hsp90蛋白抑制肝癌的生物碱类成分的快速发现及作用机制研究,57万元,2019-2022,参与
代表性学术论文
1、Yu-Xi Wang, Zhi-Yong Xu, Shu-Yan Qin, Ning-Ning Du, Guo-Dong Yao, Bin Lin, Xiao-Xiao Huang*, Shao-Jiang Song*. Novel Bisamide Alkaloids Enantiomers from Pepper Roots (Piper nigrum L.) with Acetylcholinesterase Inhibitory and Anti-Neuroinflammatory Effects [J]. Journal of Agricultural and Food Chemistry, 2022, 70(49): 15487-15498.
2、Yu-Xi Wang, Feng-Ying Han, Zhi-Kang Duan, Ye Chang, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang*, Guo-Dong Yao*, Shao-Jiang Song*. Phenolics from Archidendron clypearia (Jack) I.C.N. protect SH-SY5Y cells against H2O2-induced oxidative stress [J]. Phytochemistry, 2020, 176: 112414.
3、Yu-Xi Wang, Le Zhou, Jie Wang, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang*, Shao-Jiang Song*. Enantiomeric lignans with anti-β-amyloid aggregation activity from the twigs and leaves of Pithecellobium clypearia Benth [J]. Bioorganic Chemistry, 2018, 77: 579-585.
4、Yuxi Wang, Jinghui Jia, Qi Wang, Yulian Wei, Haisheng Yuan*. Secondary metabolites from the cultures of medicinal mushroom Vanderbylia robiniophila and their tyrosinase inhibitory activities [J]. Journal of Fungi, 2023, 9(7), 702-714.
5、Yu-Xi Wang, Bin Lin , Le Zhou, Zhi-Yang Yan, Han Zhang, Xiao-Xiao Huang*, Shao-Jiang Song*. Anti-β-amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia (Jack) I.C.N [J]. Natural product research, 2020, 34(4): 456-463.
6、Yu-Xi Wang, Zhi-Kang Duan, Ye Chang, Zhi-Yang Yan, Xiao-Bo Wang, Xiao-Xiao Huang*, Shao-Jiang Song*. Triterpenes from Archidendron clypearia (Jack) I.C.N. with anti-β-amyloid aggregation activity [J]. Natural Product Research, 2021, 35(16): 2789-2792.
7、Yu-Xi Wang, Qiang-Ren, Zhi-Yang Yan, Wei Wang, Lu Zhao, Ming Bai, Xiao-Bo Wang , Xiao-Xiao Huang*, Shao-Jiang Song*. Flavonoids and their derivatives with β-amyloid aggregation inhibitory activity from the leaves and twigs of Pithecellobium clypearia Benth [J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 4823-4827.
8、Yu-Xi Wang, Zhi-Kang Duan, Wan-Yi Shi, Ye Chang, Xiao-Xiao Huang*, Shao-Jiang Song*. A new dilignan from the twigs and leaves of Archidendron clypearia [J]. Journal of Asian Natural Products Research, 2021, 23(6): 609-614.
9、王雨曦, 袁海生*.槐生拜尔孔菌(槐耳)的化学成分及其抗肿瘤活性研究进展[J].菌物学报,2021,40(03):411-422.
10、贾景辉, 刘志强, 王雨曦*, 魏玉莲, 袁海生*. 槐生拜尔孔菌(槐耳)中的甾体类化合物及其酪氨酸酶抑制活性[J]. 菌物学报:1-17.
专利申请
1、袁海生,王雨曦,魏玉莲,秦问敏,窄孢灵芝中三萜类化合物及其制备方法和应用,申请号:202211399082.2,申请时间:2022.11.9
2、袁海生,王雨曦,贾景辉,魏玉莲,秦问敏,槐耳中甾体类化合物及其制备方法和应用,申请号:202211721250.5,申请时间:2022.12.31
3、宋少江,黄肖霄,王雨曦,常晔,具有神经保护活性的多酚类化合物及其制备方法,专利号:ZL201910778418.8,授权时间:2021.6.18
4、宋少江,黄肖霄,段志康,王雨曦,鄢志扬,臭椿根皮总生物碱及制备方法和应用,专利号:ZL201910195770.9,授权时间:2021.7.9
5、宋少江,黄肖霄,段志康,王雨曦,猴耳环中三萜类化合物及其制备和应用,专利号:ZL201910571795.4,授权时间:2021.6.1
6、宋少江,黄肖霄,段志康,任强,王雨曦,愈创木烷倍半萜及其制备和应用,专利号:ZL201910288536.0,授权时间:2021.3.23